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Supplemental imaging modalities for breast cancer screening in women with dense breasts: A systematic review with economic considerations

Sinéad N. DuggaSinéad N. Duggan a
,
Mohammad Azharuddin b
,
Rodolfo Hernández b
,
Clare Robertson c
,
David Cooper c
,
Emma McCall a
,
Paul Manson c
,
Gianni Virgili a
,
Mike Clarke a
,
Shaun Treweek c
,
Miriam Brazzelli d

Dec 3, 2025

https://doi.org/10.1016/j.breast.2025.104668

"Highlights

  • •

    Nearly half of the women invited for breast cancer screening have dense breasts.

  • •

    Breast density increases the risk of breast cancer and the likelihood that mammography will miss it.

  • •

    Supplementary MRI detects 19 additional cancers per 1000 screenings in those with dense breasts.

  • •

    Supplementary DBT and ultrasound detect only 2-3 additional cancers per 1000 screenings.

  • •

    Contrast-enhanced mammography detected a similar number of additional cancers as MRI, based on a single study."

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